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Description:Abstract Biological effects of sex steroids estradiolbeta, E2; progesterone, P; medroxyprogesterone acetate, MPA; Danazol, DZ and growth factors epidermal growth factor, EGF; transforming growth factor, TGF-alpha,beta on migration and invasion of endometrial adenocarcinoma SNG-M cells were investigated by haptotactic migration and haptoinvasion assay. The enzymatic degradation of the extracellular matrix by tumor cells was also examined. Tumor cell migration along a gradient of substratum-bound fibronectin was inhibited by 0.